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1. Factors Influencing Polymorphic Transition of Hyoscine N-Butyl Bromide.

    T.Arafat, M.Saleh and A.Badwan.

    Drug Development and Industrial Pharmacy. 14(15-17), 2127- 2142 (1988).


 2. Physicochemical Study of Terfenadine Glassy State.

    M.Sheikh Salem, M.Hassan, H.Alkaysi, T.Arafat, A.Abumalooh

    and A.Badwan.

    International Conference of Pharmaceutical Technology. Paris.

 3. Levelling off the Effect of particle Size on Dissolution in Spironolactone Tablets.

    A.Badwan, Nabulsi, M. Saleh, and T.Arafat.

    International Conference on Pharmaceutical Technology. Paris.

 4. Bromhexine Determination by Diazotization Using Potentiometric Titration.


    Analytical Letter, Vol. 2, 1990.


5. Physicochemical Properties of Ethinyloestradiol

     E.Sallam, N. Salman, T. Arafat, and R. Zaru.

     6th Pharmaceutical Technology Conference, Paris. June 1992


 6. Dissolution Characteristics of Interactive Powder Mixtures.

    E.Sallam, H.Ibrahim, M.Takieddinin, T.Baghal, M.Saket, R.Awad

    and T.Arafat.

    8th Pharmaceutical Technology Conference, Monte Carlo. June 1994


 7. Studies Relating to the Content Uniformity of Suppositories.

    E.Sallam, H.Ibrahim, M.Takieddin M.Saket, R.Awad, T.Arafat

    and M. Othman.

    Drug Development and Industrial Pharmacy, 15(14-16), 2653-2673, 1989.



 8. A Bioequivalence Study of two Products of Ranitidine Tablets.

    M.Saket, T.Arafat, R.Awad, H.Ibrahim, M. Saleh, E.Sallam,  

    S.Zmeili and M.Gharaibeh.

    Current Therapeutic Research, Vol. 46, 5, 924-931, 1989.



 9. A bioequivalence Study of two Products of Dipyridamole Tablets.

    T.Arafat, M.Saket, R.Awad, H.Ibrahim, M.Saleh, M.gharaibeh,

    E.Sallam and M.Shber.

    International Journal of Clinical Pharmacology Therapy and Toxicology. vol.  

     27, 11, 564-567, 1989.


 10. Analysis of Ranitidine in Plasma using High Pressure Liquid


      T.Arafat, M.Saket, R.Awad, M.Saleh, E.Sallam and M.Gharaiabeh

      Alexandria Journal of Pharmaceutical Science. 1990.


11. High-Performance Liquid Chromatography (HPLC) Determination of

      Nifedipine in Human Serum.

      T.Arafat, Y.Al-Qussuis, H.Mouti, S.Zmieli, S.Judeh and O.Shaheen.

      Dirasat,Vol. 17, Number 3, 1990.


12. Terfenadine

      A.Badwan, H.Alkaysi, L. Owis, M.Salem and T.Arafat.    

      "Analytical Profile of Drug Substances" .Vol. 19, 627-661, 1990.


13. Some Formulation Aspects of Terfenadine Solid Dispersion.

      A.Badwan, A.Abumallh, L.Owis, M.Salem, H.Alkaysi and T.Arafat

      Eur. J. Pharm. Biopharm, 37(3), 166-170, 1991.


14. Pharmacokinetics and Pharmacodynamics of Two Commercial Oral Nifedipine  


      O.Shaheen, S.Zmeili, Y.Al-Qussuois, T.Arafat and H.Mouti.

      International. J. of Clinical Pharmacology, Therapy and Toxocology. Vol.29  

      (9), 337-341, 1991.  



15. A Bioequivalence Study of Two Products of Furosemide Tablets.

      R.Awad, T.Arafat, M.Saket, M.Saleh, M.Gharaibeh, S.Zmeili,

      E.Sallam, M.Shubair and S.Qobrosi

      International J. of Clinical Pharmacology, Therapy and Toxocology.Vol.

      30 (1), 18-23, 1992.


16. Tenoxicam Polymorphic Modifications

      L.Nabulsi, L.Owais, T.Arafat and A.Badwan.

      6th International Conference on Pharmaceutical Technology, Paris, June, 1992.



17. Pharmacokinetics and Pharmacodynamics of Two Oral Formulations of  

     Metformin Hydrochloride.

    T.Arafat, A.Kaddoumi, M.Shami and M.Yassin.

    Advances In Therapy, Vol. 11, No.1, 21-33, 1994.



18. A Bioequivalence Study of Two Brands Of Captopril Tablets.

      T.Arafat, A.Kaddoumi, N.Al-Muhtasib, M.Shami, M.Yassin and

      A.Jehanli. Advances In Therapy, Vol. 11,  No .6,  320-330,  1994.


19. A Liquid Chromatographic Method For The Determination of  Norfloxacin in



      Alex. J. Pharma. Sci., Vol. 9(1), February, 1995.


20. Determination of Cisapride in Biological Samples.

      T.Arafat, M.Shami, A.Kaddoumi, A.Badwan and M.Yassin.

      Alex. J. Pharma. Sci., Vol., 9(1), February, 1995.



21. Determination of Terfenadine in Commercial Dosage Forms By

     Spectrofluorimetry and High Performance Liquid Chromatography

      T.Arafat and A.Kaddoumi.

      Alex. J. of  Pharma. Sci. Vol., 9 (2),  113 , June.1995.



22.Determination of Captopril in Human Blood by an Enzyme - Linked

     Immunosorbent  Assay.

     A. Jehanli, T. Arafat and M. Al-Shami

     J.Pharma. Pharmacology, Vol. 48, (914-917), 1996.


23. Ibubrofen Sustained -  Release Dosage Forms.

       M.Gharaiabeh, T.Arafat and E. Sallam.

       Clinical Drug Investigation, Vol.11, (3), 174 - 183, 1996


24. Pharmacokinetic and Pharmacodynamic Profiles of Two Brands of Amlodipine                        

      Determined by Enzyme Linked Immmunosorbent Assay

      K.Matalka, T.Arafat, T.El-Thaher, K. Qawasmeh, S. Shebli, M.Hamad and

      A. Badwan.

       J.Pharm. Pharmacol. Commun. Vol. 6, 539- 544, 2000.      


25. Enzyme Linked Immunosorbent Assay for Determination of Amlodipine in


        K.Matalka, T.El-Thaher , Mohammad Saleem, T.Arafat, , Ahmed Jehanli  

        and A. Badwan.

       J.of Clinical Laoratory Analysis. Vol. 15, 47- 53, 2001.      


26. Assessment of a controlled release hydrophilic matrix formulation for

      metoclopramide HCl.

      Enas Hasan, Bassam Amro, Tawfiq Arafat, Adnan Badwan

     European Journal of Pharmaceutics and Biopharmaceutics 55 (2003) 339-344.


27. Pharmacokinetics and pharmacodynamics profiles of enalapril maleate in

      healthy volunteers following determination of enelapril and enalaprilat by two

     specific enzyme  immunoassays 

       T.Arafat, et al. Journal of Clinical Pharmacy and Therapeutics,  June {2005}, 30, 1 - 10


28. Effect of Steric bulk and stereochemistry on the rates of diketopiperazine  

      formation from N-aminoacyl-2,2-didimethylthiazolidine-4-carboxamidee

     (dipeptideamides) – a model for a new prodrug linker system.                      

     Ghadeer A.R. Suaifan , Mary F. Mahon, Tawfiq Arafat, and Michael D.


     Tetrahedron 62, (2006) 11245- 11266.      


29. A trend of low serum Vit. B12 in Jordanian adults from two ethnic groups in


      Nancy Hakooz, Rana Abu- Dahab, Tawfiq Arafat and Mohammed Hamad.

      Jordan Medical Journal, Vol; 40, no: 2 page 80-87 , 2006.


30. Validated liquid chromatographic–ultraviolet method for the quantitation  of  

      tadalafil in human plasma using liquid–liquid extraction.

      Ashok K. Shakya a,∗, Ahmed N.A. Abu-awwad b, Tawfiq A. Arafat b,

      Munther  Melhim.

     J. of Chromatography  and biomedical Application

      accepted 29 January 2007


31. Synthetic approach to peptides containing the L-Gln-L Val-D(s) Dmt Motif

      Ghadeer A.R. Suaifan , Tawfiq Arafat, and Michael D. Threadgill

       Bio0rganic and Medicinal Chemistry, Volume 15, (2007), 3474 - 3488.      


32.Population Pharmacokinetics of Atorvastatin, Simvastatin & Pravastatin

    After Oral Administration in Humans

    Naser M.Idkaidek , Naji M. Najib, Tawfiq Arafat and Ahmad Al-Ghazawi

    Saudi Pharmaceutical Journal, Vol. 16, No. 1, January 2008


33. Smoking behavior modulates pharmacokinetics of orally administered


     A.M Yousef Ph.D, Tawfiq Arafat, Ph.D, N.R. Bulatova Md. Ph.D, and R.Al-  

     Zumyli, B.Sc

     Journal of Clinical Pharmacy and Therapeutics, (2008) 33, 439- 449.      



34. Simultaneous Determination of Triprolidine and Pseudoephedrine in Human

      Plasma by Liquid Chromatography-ion trap mass spectrometry

      Ashok K. Shakya*1, Tawfiq A. Arafat2¶, Ahmad N. Abu awwad2,Munther

      Melhim2, Jafar Al-Ghani2 and Mahmoud J. Yacoub2

      Journal of Chromatography B, 2009



35. Tamsulosin quantification in human plasma by high performance liquid

      Chromatography coupled to electrospray tandem mass spectrometry

      Ashok K. Shakya1, Nancy M. Hakooz, Tawfiq A. Arafat, Ahmed N.A. Abu-  

      awwad, Jafar AbdEl-Ghani and Munther Melhim

      Acta Chromatographica Journal, volu.22, 2010, 99-116


36. Simple and rapid HPLC method for the determination of alfuzosin in human  


     Ashok K. Shakya1, Tawfiq A. Arafat, Ahmad Abuawaad, Hamza Al-Hroub,    

     Munther Melhim

     Jordan Journal of Pharmaceutical Sciences, volume 3, 2010, 25-36


37. Genetic Analysis of Thiopurine  Methyl Transferase Polymorphisim in  

      Jordanian Population

      Nancy Hakooz, Tawfiq Arafat, Debbie Payne, William Ollier, Julie Andrews    

       and William Newman

       Poster Presentation in Portugal


38. Bioadhesive controlled metronidazole release matrix based on chitosan and

      xanthan gum.

      Eftaiha Ala'a F; Qinna Nidal; Rashid Iyad S; Al Remawi Mayyas M; Al Shami                                                  

      Munther R; Arafat Tawfiq A; Badwan Adnan A

      Marine drugs 2010;8(5):1716-30.


39. Enhancement of Oral Bioavailability of Insulin in Humans

      Adnan Badwan, mayas Remawi, Amani Elsayed, Tawfiq Arafat, Munther  

      Melhim, Omar Abu Hijleh, and naser Idkaidek,

      Neuroendocrinology letters, Volume 30 No,1 , 2009, 101 - 105



40. Effect of Licorice Drink on the Systemic Exposure of Verapamil in Rabbits

      Ibraheem D.Al-Deeb, Tawfiq Arafat and Yacoub M. Irshid

       Drug Metabolism Letters,2010, 4, 173-179


41. Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans

      Nasir Idkaidek,Ph.D.* , Tawfiq Arafat, Ph.D.

      Accepted for Publication,in Journal of Clinical Pharmacology, 2011

42. Influence of Genetic Variation in Enzyme CYP2C19 and the Effect on the

      Pharmacokinetic Profile of Lansoprazole, Screening the Allele frequencies of    

     CYP2C19*1,  CYP2C19*2 and CYP2C19*3 in the Jordanian Population.

     Nancy Hakooz. Imad Zallom and Tawfiq Arafat

     Oral  Presentation in Kuwait, 2011


43. Effect of Mint Drink on metabolism of Nicotine as measured by Nicotine to  

     Cotinine Ratio in Urine of Jordanian Smoking Volunteers

    Abdulrahman Ghazi, Abdulazim Salhab, Tawfiq Arafat, and Yacoub irshaid

    Nicotine and Tobaco Research, 2011, (1-7).


44. The Effect of Ethyl Acetate Extracts of Pomelo Mix on Systemic Exposure of  

     Verapamil in Rabbits.

    Suad Aqel, Yacoub Irshaid, Munir Gharaibeh and Tawfiq Arafat

    Drug Metabolism letters, 2011, 5, 92- 98


45. Genetic polymorphism of CYP2C19 in a Jordanian population:

      influence of allele frequencies of CYP2C19*1 and CYP2C19*2

      on the pharmacokinetic profile of lansoprazole

       Imad Zalloum • Nancy Hakooz • Tawfiq Arafat

       Mol. Biol Rep, July 2011,



46. Plasma concentrations of 25-hydroxyvitamin D among Jordanians:  

      Effect of biological and habitual factors on vitamin D status

      Eyad M Mallah1*, Mohammad F Hamad2, Mays A ElManaseer3, Nidal  

      Qinna2, Nasir M Idkaidek3, Tawfiq A Arafat1and Khalid Z Matalka2

      BMC Clinical Pathology 2011, 11:8


47. Metformin IR versus XR Pharmacokinetics in Humans

      Nasir Idkaidek, Tawfiq Arafat, Munther Melhim , Jaafar Alawneh and Nancy


      Journal of Bioequivalence & Bioavailability , 2011, 3 (10), 233 -235.


48. UDP-glucoronosyltransferase 1A4(UGTIA4) polymorphisms in a Jordanian


      Nancy Hakooz, Sameh Alzubiedi, Al-Motassem Yousef, Tawfiq Arafat,

      Rana Dajani, Nidaa Ababneh, Said Ismail

     Mol. Bioi Rep. 25, February, 2012.


49. Saliva versus Plasma Pharmacokinetics, Theory and Application of a Salivary

      Excretion Classification System"

      Idkaidek, Nasir; Arafat, Tawfiq

     Molecular Pharmaceutics, 2012, 9, , 2358 - 2363





    Nidal A. Qinna 1,*, Eyad M. Mallah 2, Tawfiq A. Arafat 2 and Nasir M.


    International journal of Pharmacy and Pharmaceutical Sciences , vol. 4, issue 4,

    158-162, 2012


51. High Performance Liquid Chromatographic Determination of Montelukast

     Sodium in Human Plasma: Application to Bioequivalence Study

     Ashok K. Shakya, Tawfiq A. Arafat, Nancy M. Hakooz, Ahmad N.  

     Abuawwad, Hamzea Al-Hroub , Munther Melhim

    Acta Chromatoghraphia, Accepted, 04/12/2012.



52: Pharmacokinetics of 600 mg Loading Dose of Clopidogrel in Patients

      Undergoing Percutaneous Coronary Intervention.

      Al-Motasem Yousef, Ola Diab, Tawfiq Arafat, Akram El-Saleh, Hamzah Al-


       Journal Of Biomedical Chromatography, Accepted on 27 of September, 2012.


53. Development and Valdation for some Azoles in Pharmaceutical Preparation

      Wael Abu Dayyih, Noor Al saadi, Mohammad Hamad, Eyad Mallah, Khalid  

       Matalka, and Tawfiq Arafat

       International Journal of Pharmaceutical Sciences and Research, 2012, Vol.



54. Simultaneous Determination of Amlodipine and Atorvastatin with Its

       Metabolites; Ortho and Para Hydroxy Atorvastatin; in Human Plasma by LC-


       Mahmoud Yacoub, Ahmad Abu awwad, Mahmoud Alawi, Tawfiq Arafat

       PII: S1570-0232(13)00021-4

       Journal of Chromatography B Received date: 28-9-2013

       Accepted date: 1-1-2013


55. A Stability – Indicating High Performance Liquid Chromatographic (HPLC)

     Assay for the Determination of Cefachlor in Biological  Fluids

     Wael A abu Dayyih,  Eyad mallah, Fiasel T. Al-Akayleh, Mohammed F.

     Hamad  and Tawfiq Arafat

     Latin American Journal Of Pharmacy.

     Accepted Date: 28/02/2013


56. Population pharmacokinetic analysis of clopidogrel in healthy Jordanian

       subjects with emphasis optimal sampling strategy.

       Yousef AM, Melhem M, Xue B, Arafat T, Reynolds DK, Wart SA

       Biopharm Drug Dispos. 2013 Mar 5. doi: 10.1002/bdd.1839.


57.Method Development, Validation and Bioequivalence of Varenicline in

     Human Plasma by Liquid Chromatography Tandem Mass spectrometry

     Ayoub Al-Haj, Mahmoud Alawi, Tawfiq Arafat, Mohammad Khair

     Hourani, Journal Chromatography B, accepted, 2013.


58. Development and Validation of a stability –Indicating HPLC Method for

      Determination of Buoivacaine in Human Plasma.

      Wael Abu Dayyaih, Enas Alkhader, Eyad Mallah and Tawfiq Arafat

      International Journal of Pharmaceutical Analysis, 2051-2740, vol.38,

      Issue 2, 2013


59. Study the Influence of Low Fat Content Test Meal on

      Cyclobenzaprine Bioavailability in Human Body by Using


      Ahmad Abu awwad1, Mahmoud Yacoub2, Mahmoud Alawi3* and

     Tawfiq  Arafat4

     International Journal of Research in Pharmaceutical and Biomedical

    Sciences, Vol. 4 (4) Oct – Dec 2013


60. Saliva versus Plasma Bioequivalence of Paracetamol in

      Humans: Validation of Classes I and II Drugs of the Salivary Excretion

       Classification System :

       Idkaidek, Nasir; Arafat, Tawfiq Drug Res (2014)


61. Saliva versus Plasma Bioequivalence of Metformin in

      Humans: Validation of Classes I and II Drugs of the Salivary Excretion

       Classification System :

       Idkaidek, Nasir; Arafat, Tawfiq

       Drug Res. 2014, vol. 64, page 599-602


62. Pomegranate Juice Effects on Pharmacokinetic Parameters of

       Metronidazole by Using HPLC-MS

       Haifa T. Abu Tabeekh, Wael A. Aby Dayyih, Eyad M.Mallah, Nidal A.

       Qinna, Riad Awad, Tawfiq A. Arafat

      World Journal Of Pharmacy and Pharmaceutical Sciences, Vol. 3,

      Issue 7, 150 -164, 2014.


63.Synthesis of 2-{4-(t-amino-1-yl) but-2-yn-1-yl} oxy-1,3- benzothiazole

     derivatives as H3-antagonists.

     Ragheed Al-Rahmani, Elham Al-Qaissi, Tawfeeq Arafat, mohammad

    Ghattas, Zuhair Muhi-eldeen

    JOSR Journal of Pharmacyvol. 4 issue 9 (September 2014) 41 – 49.


64. Pethidine level In Jordanian Women and their Newborns during Labor

       after a Single Intravenous Dose.

       Wael Abu Dayyih, Dania El Tannir, Eyad Mallah, Mohammad Hamad,

       Naser Idkaidek, Riad Awad, Abdul Fattah Salem, and Tawfiq Arafat

       International Journal of Clinical Anesthesiology vol. 2, 1032, 2014


65.  Determination of loperamide in human plasma and  saliva by liquid

       chromatography-tandem mass spectrometry,

       T.A Arafat, B.T Arafat, R. Awad, A. Abu awwad, (2014).

       Journal of chromatography B. 972: 81- 88.


66. Simultaneous Determination of Atorvastatin, Glimepiride and Amlodipine in

      Solution and Plasma Matrix Using HPLC/UV Method

      Wael Abu Dayyih, Alaa Al-fayez, Lina Altamimi, Eyad Mallah, and Tawfiq


     Journal of Chemical and Pharmaceutical Research  Vol.6   (11),  515- 528,



67.  Simultaneous Determination of Sildenafil and Glimepiride in Rat Plasma by

       Using Lc-Ms Method and their Applications in Pharmacokinetic Interactions

       Eyad Mallah1*, Nibras Al Ani1, Wael Abu Dayyih1, Nidal Qinna2, Riad

       Awad1, Kamal Sweidan3 and Tawfiq Arafat1

      J. Clinical Pharmaceutics , 1,(2), 1007, 2014


68. Pioglitazone HCL Levels and its Pharmacokinetic Application in Presence of

       Sucralose in Animals Serum by HPLC Method

       Lina Tamimi, Wael Abu Dayyah, Nidal Qinna, Eyad Mallah and Tawfiq


       Pharmaceutica Analytica Vol.5, (9), 2014, 1-9


69. Evidence of reduced oral bioavailability of paracetamol in rats following

       multiple ingestion of grapefruit juice

       Nidal A. Qinna, Obbei A. Ismail, Tawfiq M. Alhussainy, Naser M. Idkaidek.,    

      Tawfiq A. Arafat

       Eur. J. Drug Metabolism and Pharmacokinetics, 2014.



70. Comparative bioavailability of two different quetiapine doses (50 and 200 mg)

      in healthy volunteers by using LC/MS.

      Eyad Mallah, Basel Arafat, Ahmad Abu Awwad, Wael Abu Dayyih,

      Mohammed Mima and Tawfiq Arafat

      Journal of Chemical and Pharmaceutical Research, 2014, 6 (12)559 – 569



71. Simultaneous determination of Paracetamol and its Metabolites in Rat Serum

       by HPLC Method and its Application Supplement-Drug Pharmacokinetic


       Bayan Alkhawaja, Tawfiq Arafat, Eyad Mallah, Nidal Qinna, Naser Idkaidek,

       Wael Abu Dayyih, Hamza Alhroub and Adnan Badwan.

        International Journal of Pharmaceutical Analysis, vol,39, issue, 2, 2740 -  

        2751,        2014


72. Saliva Versus Plasma Bioequivalence of Rosuvastatin in Humans: validation of

      Class III Drugs of the Salivary Excretion Classification System.

      Naser Idkaidek, Tawfiq Arafat

      Drugs Research and Development, Accepted 2014,


73. Determination of Atorvastatin Pharmacokinetic Parameters by LC/MS-MS

      with Traditional Liquorice Beverage.

      Teeba Al. Shaikhli1, Wael Abu Dayyih1,*, Eyad Mallah1, Mohammed

      Hamad2,  Nidal Qinna1, Tawfiq Arafat1,3

      Scientific & Academic Publishing, 2015


74. Saxagliptin Levels and its pharmacokinetic Application in Presence of

     Sucralose in Animals Serum by HPLC Method

    Wael Abu Dayyih, Lina Tamimi, Eyad Mallah, Kenza Mansour, Tawfiq Arafat,  

    Mona Bustami    International Journal of Pharmacy and Pharmaceutical

  Sciences, Vol, 5ssue 9,

   1-8, 2015


75. Cyclopropan Formation Versus Sigmatropic Rearrange products in the

      Ethylenediazzacetate Addition to Allyl Thiotetrapyran

      Zuhair Muhi-Eldeen, Tawfiq Arafat, Elham Alqaissi

      European Journal of Pharmaceutical Research, vol. 2, 1058- 1065, 2015


76. Serum concentrations of magnesium among Jordanians: Effect of

       Cardiovascular disease on magnesium levels.

       Sally Oumeish, Eyad Mallah, Wael Abu Dayyah, Mohammed Hamad, Walid

       Abu Rayyan, Mona Bustami and Tawfiq Arafat

       Journal of Chemical and Pharmaceutical Research, 2015, 7 (11) 499 – 503


77. Sensitive and Rapid HPLC-Uv method with back extraction step for the

       determination of sildenafil in human plasma

       Hamzah Al-Hroub, Bayan Alkhawaja, Eman Alkhawaja, Tawfiq Arafat

       Journal of Chromatography B, 2015, 1009, 1-6.


78. Relative Bioavailability of Ciprofloxacin Doses (750 and 1000) mg in healthy

       Male Volunteers by using HPLC method

      Mallah E, Arafat B, Alkhawaja B, Abu Dayyih W, Abu Awad A, Hroub HA,

      and  Arafat T.

      Journal of Bioequivalence Studies Vol. 1, Issue 1, 1 -6 , 2015


79. Determination of carbamazepine in rat plasma in the presence of licorice juice

       by using HPLC and its pharmacokinetic applications

      Moh,d Salemaldajeh, Eyad Mallah, Riad Awad, Basma A. Othman and Tawfiq


     Journal of Chemical and Pharmaceutical Research, 2015, 7(12) : 116 – 1216



80. Synthesis and characterization of a-amino – n-phenyl succinimide as precursor

       for corresponding thionimides

      Ibrahim Al Adham, Zuhair muhi-Eldeen, Elham Al-Kaissi, Tawfiq Arafat,

      Bahaa Shafiq

      European Journal of Pharmaceutical and Medical Research, vol. 2, (7),

      74 - 86, 2015

81. Liquorice beverages effect on the pharmacokinetic parameters of atorvastatin,

      simvastatin, and lovastatin by liquid chromatography- mass spectroscopy

      Wael Abu Dayyih, Eyad Mallah, Israa Al-Ani, Tawfiq Arafat

      Asian Journal of Pharmaceutical and Clinical Research, vol. 9 Issue 2,



82. Nationality, Gender, Age and Body Mass Index Influences on Vitamin D

      Concentration among Elderly Patients and Young Iraqi and Jordanian in


     Biochemistry Research International, Volume, 2016

     Hanan Al-Hourani, Wael Abu Dayyih, Eyad Mallah, Mohammed Hamad,

     Mohammed Mima, Riad Awad, and Tawfiq Arafat


83. A study of the Possible Effect of Pomegranate juice on the Pharmacokinetics of

      Candesartan in Rat Plasma by using a Bio analytical Method Liquid

      Chromatography / Mass Spectrometry (HPLC/Ms/Ms)

       International Journal of Pharmacy & Technology, vol. 8, Issue 1, 10200 –

       10216, 2016

        Ahmed Al-Kawaz, Wael Abu Dayyih, Eyad Mallah, Mohammed Hamad,

        and Tawfiq Arafat


84. Simultaneous Estimation of Esomeprazole and Tadalafil in Pharmaceutical

       formulations using High Performance Liquid Chromatography.

       Journal of applied pharmaceutical Science Vol 6 (04), pp 052 – 059 April,


      Mohammed Hamad,  Ahmed Al-Sharqawee,  Wael Abu Dayyih, Eyad Mallah,

        and Tawfiq Arafat


85. Determination of Fenofibric Acid in Human Plasma by LC/MS/MS and


     Chromatographia Journal, April 2016

     Tawfiq Arafat, Basil Arafat, Ahmad Abu Awwad & Oliver J. Schmitz


86. Oxidants and Antioxidants As Risk Factors In Young Arabian Male Patients

      With Acute Myocardial Infraction

      Najah Al-Muhtaseb, Elham Al-Kaissi , Zuhair muhi-Eldeen, , Tawfiq Arafat,

      Sabah Al-Muhtaseb, Hani Atiyah.

      International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, 273-

     277, 2016



87. Dose-Dependent Synergistic effect of Pomegranate Juice on the

      Bioavailability of Sildenafil in Rats by Using HPLC Method

      Latin American Journal of Pharmacy, 35, (6), 1277 – 1284 , 2016

      Eyad M. MALLAH , Walid S.A. RAYYAN, Wael A.A. DAYYIH, Feras D.  

      ELHAJJI,  Kenza A. MANSOUR , Ibrahim S. AL-MAJALI  & Tawfiq A.



88.  Study the Influence of Licorice and Pomegranate Drinks on Nicotine

      Metabolism in Human Urine by Lc-orbitrap MS

      Journal of Pharmaceutical and Biomedical Analysis, 2016

     For authors: Ahmad Abu awwad, Tawfiq Arafat, Oliver J. Schmitz*



89- Simultaneous determination of nicotine, cotinine and nicotine N-oxide in

      human plasma, semen and sperm by LCOrbitrap MS

     Analytical & Bioanalytical Chemistry , 2016

     Ahmad Abu awwad, Tawfiq Arafat, Oliver J. Schmitz*


90. Preparation of chito-oligomers by hydrolysis of chitosan in presence of

      zeolite as adsorbent"

      marine drugs, , 14, 43, 2016

      Khalid A. Ibrahim , Bassam El-Eswed , Khaleel Abu-Sbeih , Tawfeeq Arafat ,

     Mahmoud M.H. Al Omari , Fouad H. Darras and Adnan A. Badwan


91. Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-  

      regulation of HIF-1α and sphingosine kinase 1

     Accepted in Oncotarget

     Heba Alshaker; Q.Wang1; yoshiaki.kawano; Tawfiq Arafat; torsten.bohler;    

      Mathias.Winkler; Colin.Cooper


92. Investigation of possible pharmacokinetic interaction of metformin with sugar

      replacement sweeteners in rats

      Journal of Applied Pharmaceutical Science Vol.6, (10), pp 2010 -215 , 2016

      Riad Awad,  Eyad Mallah, Israa Al-Anni, Wael Abu Dayyih, Zianab Zakarya

       and Tawfiq Arafat



93. Saliva Versus Plasma Bioequivalence of Azithromycin in Humans: Validation

      of Class 1 Drugs of the Salivary  Excretion Classification System

      Drugs Research and Development, 2017

     Naser Idkaidek, Tawfiq Arafat, Hazim Hamadi, Salim Hamadi


94. Ring opening of cyclobutane in 1,3-dimethyl-5-methylene barbituric acid

       dimer by various nucleophiles

       DE GRUYTER, Z. Naturforsch, 2017, 72, (5) b: 377 – 382

       Kamal Swiedan, Wael Abu Dayyih, Murad AlDamen, Eyad Mallah, Tawfiq

      Arafat, Mustafa El-Abadelah, Hanadi Salih and Wolfgang Voelter


95. Pharmacokinetics and Pharmacodynamics Interaction of Warfarin in the

      Presence of Beverage Juices (Licorice and Pomegranate) in Rat Plasma by

      Using LC/MS

      Latin American Journal of Pharmacy, 36, (6), 1181 – 1192 , 2017

      Mohammed Mima, Eyad Mallah, Wael Abudayyih, Feras Elhaji, Hanadi Salih,

      Zainab Zakarya, Basma Othman, & Tawfiq Arafat.


96.  Combination of RAD001 (everolimus and docetaxel reduces prostate and

       breast cancer cell VEGF production and tumor vascularization

       Independently of sphingosine – kinase -1

       Heba Alshaker; Q.Wang1; torsten.bohler; Robert Mills, Mathias Winkler;

       Tawfiq Arafat; yoshiaki.kawano;, and Dimitri Pshejetski.



97. Study of forced degradation behavior of amisulpride by LC-MS and NMR and

        development of a stability-indicating method

       Kamal Sweedan ; Mohammad Elayan ;  Dima Sabbah ;  Gada Idrees   ;

      Tawfiq Arafat

     Current Pharmaceutical Analysis, vol. 13, 2017


98.  A Liquid Chromatography-Tandem Mass Spectrometry Method for Evaluation

          of Two Brands of Enalapril 20 mg Tablets in Healthy Human Volunteers.

          Journal of Analytical Methods in Chemistry Volume 2017,

          Wael Abu Dayyih, Mohammed Hamad, Ahmad Abu Awwad, Eyad Mallah,

           Zainab Zakarya, Alice Abu Dayyih, Tawfiq Arafat.


99. The Influence of Eruca Sativa (Argula) on on Pharmacokinetics of Sildenafil in


      Neuroendocrinology letters, Volume 38, No. 4, (101- 107), 2017.

      Eyad Mallah, Soadad Saleh, Walid Abu Rayyan, Wael Abu Dayyih,

      Feras Darwish Alhajji, Mohammed Mimi, Riad Awad, and Tawfiq Arafat.


100. Saliva Versus Plasma Bioequivalence of Valsartan/ Hydrochlorothiazide in

         Humans: Validation of Class II and IV Drugs of the Salivary  Excretion

        Classification System

        Drugs Research and Development, 2017

        Naser Idkaidek, Haneen Agha, Tawfiq Arafat.


101.  Effects of the Genetic Variants of Organic Cation Transporters 1 and 3 on the

          Pharmacokinetics of Metformin in Jordanians

          Drug Metab Pers Ther. 2017 Sep 01.  

         Nancy Hakooz 1 , Yazun Bashir Jarrar 1 , Malik Zihlif 1 , Amer Imraish 1 , Saja

         Hamed 1 , Tawfiq Arafat 1


102.  The Effect of Some Fruit Juices on Glimeperide Pharmacokinetic in Rat

         Plasma by Using High Performance Liquid Chromatography – Mass

         Spectrometry, 2017

         Mohammed Hamad, Wael Abu Dayyih, Rafif Raad,  Alice Abu-Dayyah,

        Israa Al-Ani, Eyad Mallah, hanadeh Saleh, Zainab Zakarya and Tawfiq



103. Synthesis , Structural Elucidation of Aminoacetylenicoxyquinazoline and

        their Antiproliferative Activities.

        Detr Pharma Chemica, 2017, 9 923) :38 – 45

        Zuhair Muhi-eldeen, Bara Alani, Elham Al-Kaissi, Sana Bardaweel,

        Mohammed Ghattas, Tawfiq Arafat



104. Validation and Determination of Piracetam in Rat Plasma by Using High

        Performance Liquid Chromatography UV/ Vis, Spectrometry in Presence of

        Pomegranate and Liquorice Juices for Pharmacokinetic Study.

        International Journal of Biology, Pharmacy  and Allied Sciences, 2017,

       Mohammed Hamad, Ruba Al-Jariri, Lina Al Tamimi , Alice Abu-Dayyah,

       Wael Abu Dayyih, Eyad Mallah, and Tawfiq Arafat.


105. Establishment and Validation of a sensitive Method for Detection of

        Pregabalin in Pharmacological formulation by GC/MS

       Current Pharmaceutical Analysis,  2017

       Wael Abu Dayyih, Mohammed Hamad, Eyad Mallah, Alice Abu-

       Dayyah, Kenza Mansour, Zianab Zakarya, Riad  Awad, and Tawfiq Arafat.



106. Method Development of Vildagliptin and Metformin HCl in Pharmaceutical

        Dosage form by Reverse Phase-High Performance liquid Chromatography


       Internationa Journal of Pharmaceutical Sciences and Research  (IJPSR)


       Wael Abu Dayyih, Mohammed Hamad, Eyad Mallah, Alice Abu-

       Dayyah, Zianab Zakarya, and Tawfiq Arafat.


107. Tablet Fragmentation without a disintegrant: A novel design approach for

         accelerating disintegration and drug release from 3D printed cellulosic tablets

        Basel Arafat, Magdalena Wojsz, Abdullah Isreb, Robert Forbes, Mohammed

        Isreb, Waqar Ahmed, Tawfiq Arafat, Mohamed Alhnan.

        European Journal of Pharmaceutical Sciences, 2018.


108. Analytical and comparative Study about the Impact of Lead Homeostasis

        on Cardiovascular Disorders in Humans

        Eyad Mallah , Walid Abu Rayyan, Wael Abu Dayyih, Ibrahim Almajali,

        Haytham al Qaralleh, Osama Yousef, Nisrene Seder, Mona Bustami, Luay

        Abu Qatoosah, and Tawfiq Arafat.

        Biomedpharmajournal, 2018.



109. Synthesis , Structural Elucidation and evaluation of antimicrobial activity of

        5-ethoxy-2-mercaptobenzimidazole derivatives.

        International Journal of Medical Research & Health Sciences, 2018, 7 (5):


        Alaa Alkhafaji, Zuhair Muhi-eldeen,  Elham Al-Kaissi, Najah Al-Muhtaseb,

        Tawfiq Arafat and Mohammed Ghattas.

110.  Method  Development  and Validation of  Vildagliptin  and  Metformin  in  

        Pharmaceutical  Dosage  Form  by Reverse  Phase – High Performance

        Liquid Chromatography (RP-HPLC).

       International Journal of Pharmaceutical Sciences and Research, 2018; Vol.  

       9(7): 2965-2972  .

      Wael Abu Dayyih * , M. Hamad , E. Mallah , A. Abu Dayyih , R. Awad,  

      Z. Zakaria  and T. Arafat  


111.  Solid  Phase  Synthesis  and Antibacterial Activity of an artificial Cyclic  

        Peptide Containing Two Disulfide Bridges.

        Dassan Jaradat, Khalil Saleh, Basma Zaarer, Tawfiq Arafat, Karem Alzoubi,

       Samer Altaweel, Eyad Mallah, Moawiya Haddad, Bayan Haimour.

       International Journal of Peptide Research and Therapeutics, 2018


112. Influence of Energy Drinks on Pharmacokinetics Parameters of Sildinafil in


         Biomedicaland Pharmacology Journal, 2018

         Mohammad Abdulla,   , Eyad . Mallah ,   Wael Abu Dayyih * , Walid Abu

        Rayyan, Feras Darweesh El-Hajji,  Mona Bustami,  Kenza Mansour,  Israa

        Al-Ani,  Nisreen Seder  and T. Arafat  


113. Determination of Carbamazapine in rat plasma by using {HPLC} in presence  

      of some traditional beverages (Tamarind, Mango, Sugarcane, Red Bull) and its

      pharmacokinetic applications.

      International Journal of Biology, Pharmacy and Allied Sciences. 2018

      Reem Emad, Eyad . Mallah ,   Fatima Shain, Feras Darweesh El-Hajji, Wael  

     Abu Dayyih, Luay Abu Qatoosah, Dasan, Jaradat , and T. Arafat .

114. The Impact of the Complexity of Cystic Fibrosis in Jordanian Patients on the  

         Spectrum of Cystic Fibrosis Trans membrane Conductance Regulator


        Jordan Jornal of Biological Sciences, Vol.11, no. 17, 2018

        Mona R. Bustami1,Luay  F. Abu-Qatouseh1 , Nagham A. Hussein 2, Walid S.

       Aburayyan1, Eyad M. Mallah1, Raeda W. Khalil3 and Tawfiq A. Arafat1*


115. The Level of Acrylamide in Food items and the effect of reheating of fried

          and backed foods on Acrylamide levels

          Advances in Environmental Biology, vol.12 (11) pages 29 – 31, 2018

          Isam Jawad, Tawfiq Arafat and Marwan Al Muwalla.




        International Journal of Biology Pharmacy and Allied Health

        Luay  Abu-Qatouseh1  Mona R. Bustami1, Walid S.

       Aburayyan1, Eyad M. Mallah1, and Tawfiq A. Arafat1*


117.  Factors affecting coenzyme coobalamine (vit. B12) levels in healthy and

         patient individuals from Petra rejoin (Jordan)

         Clinical Biochemistry

         Layali Abu Aladass, Eyad Mallah, Mohammed Hamad, Wael Abu Dayyih,

         Nasir Idkaidek, Soadad Saleh, Luay Abu-Qatouseh, Mona Bustami, Tawfiq



118.  Development and validation of Liquid Chromatography Method for

         Determination of Glimperide in Presence of Vimto Soft Drinks in Rats:

         Application to Pharmacokinetic Study.

         Journal of Pharmacy and Bioallied Sciences, Vo. 11, page, 49 – 50, 2019

          Mohammed Hamad, Areej Rahhal, Wael Abu Dayyih, Eyad Mallah, Alice

         Abu Dayyih, Zainab Zakaria and Tawfiq Arafat.



119. The effect of Pomegranate and Licorice on Pharmacokinetics of Theophylline

        in Rat Plasma

        J.Pharma. Sci. 44, 1, 9 – 16, 2019

        Alhuda ALANBAKI * , Israa ALANI**, Eyad Mallah* , Zainab

       ZAKAREIA* , Tawfiq  ARAFAT* , Wael ABU DAYYIH**,

120. Facile synthesis of model 2,4-diaryl-1,3,4-thiadiazino{5,6-h}


        DE GRUYTER, 2019

       Mohammed,  Abadleh, Tawfiq Arafat, Luay Abuqatoseh, Mustafa  

       AbadlehFiras Awwadi, and Wolfgang Voelter


121. Hypoglycemic Effect of Olive Oil on Patients and healthy individuals in


       International Journal of Biology, Pharmacy and Allied Sciences, August 2019,

      8 (8): 1393 – 1402

      Amera Abudhair, Zianab Zakareia, Eyad Mallah, Wael Abudayyhe, Tawfiq

     Arafat, and Luay Abu-Qatouseh


122. An LC-MS/MS method for determination of triple drugs combination of

       valsartan, amlodipine and hydrochlorothiazide in human plasma for

       bioequivalence study

       Current Pharmaceutical Analysis

       Rana Said*, Basel Arafat, Tawfiq Arafat, Eyad Mallah.


123. Effects of the genetic variants of organic cation transporters 1 and 3 on the

        pharmacokinetics of metformin in Jordanians.

         Drug Metab Pers Ther. 2017 Sep 26;32(3):157-162. doi: 10.1515/dmpt-2019  

       Hakooz N, Jarrar YB, Zihlif M, Imraish A, Hamed S, Arafat T.



124. High performance liquid chromatography – mass spectrometric bioanalytical

        method for the determination of dapoxetine in human plasma: application for

       bioequivalence study.

      Journal of Chromatography  B

      Rana Said*, Basel Arafat, Tawfiq Arafat


125. Synthesis and characterization of some derivatives of 1,3-Diisopropyl 1-4-


       Current Chemistry litters, April , 2020

      Eyad Mallah, Kamal Swedan, Louay AbuAbu-Qattoseh, Tawfiq Arafat, and

     Ragendra Joshei



126. Evaluation of lipid lowering effect of milk thistle (silybum marianum) in  

        comparison with rosuvastatin in rats by using ACE-Alera® analyzer


        ENGINEERING DOI: 10.46300/91011.2020.14.13

        Fatima shahina , Eyad Mallaha*, Reem Emada , Luay Abu-Qatouseha , Wael

        Abu   Dayyiha , Feras Darwish El-hajjib , Kenza Mansoora , Mona

        Bostamia , Kamal Sweidanc , Tawfiq Arafat .


127. Glycemic and Insulin emic Response of multi-Grain Types of Bread

         Marketed ion Jordan

         Current Research in Nutrition and Food Science, Vol. 8 (2), 2020

        Refat Al-Kurd, Hamed Takruri, Marwan Muwalla, and Tawfiq Arafat


128. Development and Validation of Montelukast with Grape/Licorice Juices  

        and its Application to Pharmacokinetic Studies by LC/MS.

        Indonesian Journal of Pharmacy VOL 31, (3), 161 – 170, 2020.

       Mohammed Hamad, Rafif Raad, Eyad Mallah, Zainab Zakaria ,

      Tawfiq Arafat Wael  Abu Dayyih.


129. The Nutritional Value, Energy and Nutrient Contents and Claims of Marketed

        Multi-grain Breads

        Journal of Food and Nutrition Research, 2020, Vol. 8, No. 10, 600-605

        Refat Alkurd1,* , Hamed Takruri , Marwan Muwalla, and Tawfiq Arafat

130. Reproductive safety assessment of Thymus vulgaris L. extract and

        quantification of thymol sulfate in pregnant rats and fetuses using a validated

        LC/MS method of analysis

       Journal of Applied Pharmaceutical Science Vol. 0(00), pp 001-008,  

       November, 2020

       Zaineh Q. Tafesh , Kenza A. Mansoor , Nidal A. Qinna , Feras D. El-Hajji ,  

      Tawfiq A. Arafat , Luay F. Abu-Qatouseh , Bayan Y. Ghanim , Iman A.  

      Basheti  and Eyad M. Mallah


131.  The effect of grape seed and green tea extracts on the pharmacokinetics of

          imatinib and its main metabolite, Ndesmethyl imatinib, in rats

         BMC Pharmacology and Toxicology (2020) 21:77

         Ruba S. Darweesh1* , Tamam El-Elimat , Aref Zayed , Tareq N. Khamis,  

        Wahby M. Babaresh , Tawfiq Arafat and Ahmed H. Al Sharie






       Sapporo Medical Journal Volume 54, Issue 11, November 2020

       Eyad Mallah* , Razan Bardees , Luay Abu Qatouseh , Kamal Sweidan,

      Basel Arafat , Da'san Jaradat , Tawfiq Arafat


133. Age of Natural Menopause Among Jordanian Women and Factors Related to

        Premature and Early Menopause

        Risk Management and Healthcare Policy y 2021:14 199–207

        Mona Bustami, Khalid Z Matalka, Yousef Elyyan, Nagham Hussein,  Nour

       Hussein,  Nayef Abu Safieh,  Fida Thekrallah, Eyad Mallah,  Luay Abu-

       Qatouseh and  Tawfiq Arafat





         Acta Poloniae Pharmaceutica – Drug Research, Vol. 78 No. 1 pp. 11-19, 2021



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